Clinical Genetics Has a Big Problem That's Affecting People's Lives

Over the last decade, there’s been a lot of talk about reproducibility problems in science — about published results that turn out to be false alarms. In fields like psychology, neuroscience, and cell biology, these errors can send scientists down unproductive paths, waste time and money, and pollute headlines with misleading claims. "But I get much more exercised about reproducibility problems in clinical genetics, because those have massive and real-time consequences for thousands of families," says MacArthur.

Emphasize Sex in Research, orders National Institutes of Health

While experiments may be published even in a top scientific journal, other researchers who attempt to repeat the same experiments under the same conditions often find contradicting results. As a measure of this, a recent study attempted to reproduce psychology publications and successfully replicated only 39 out of 100 studies. It turns out that excluding sex in experimental design may have contributed to reproducibility issues. Furthermore, sex can also have a biological impact on our scientific understanding and influence how well early biological studies translate into advances in human medicine.