Promises, Promises, and Cell Lines: Life Sciences Researchers Talk About the Obvious Solution—Cell-Line Authentication—but They Fail To Implement It

According to a 2013 report from the American Association for the Advancement of Science, $115 billion is spent annually in the United States on life science research. Fifty percent of this total is spent on preclinical research, half of which—$28 billion—is not reproducible.

Bioethics and the reproducibility crisis

According to the mayor of Chicago, Rahm Emanuel, who is linked to bioethics through his bioethicist brother Ezekiel Emanuel, "You never let a serious crisis go to waste." In this case the crisis is the reproducibility of published results in the biological and medical sciences. According to a recent comment in Nature, "An unpublished 2015 survey by the American Society for Cell Biology found that more than two-thirds of respondents had on at least one occasion been unable to reproduce published results. Biomedical researchers from drug companies have reported that one-quarter or fewer of high-profile papers are reproducible."