Somewhere between 65 and 90 per cent of biomedical literature is considered non-reproducible. This means that if you try to reproduce an experiment described in a given paper, 65 to 90 per cent of the time you won't get the same findings. We call this the reproducibility crisis. The issue became live thanks to a study by Glenn Begley, who ran the oncology department at Amgen, a pharmaceutical company. In 2011, Begley decided to try to reproduce findings in 53 foundational papers in oncology: highly cited papers published in the top journals. He was unable to reproduce 47 of them - 89 per cent.
The authors of a highly cited 2015 paper in Nature Materials have retracted it, after being unable to reproduce some of the key findings. We’ve seen this kind of thing before, from another Nature journal, although in one case the News & Views article only earned a warning notice.
Scientific discoveries have the profound opportunity to impact the lives of patients. They can lead to advances in medical decision making when the findings are correct, or mislead when not. We owe it to our peers, funding sources, and patients to take every precaution against false conclusions, and to communicate our discoveries with accuracy, precision, and clarity. With the National Institutes of Health’s new focus on rigor and reproducibility, scientists are returning attention to the ideas of validity and reliability. At JAMA Psychiatry, we seek to publish science that leverages the power of statistics and contributes discoveries that are reproducible and valid. Toward that end, I provide guidelines for using statistical methods: the essentials, good practices, and advanced methods.
There is growing interest in enhancing research transparency and reproducibility in economics and other scientific fields. We survey existing work on these topics within economics, and discuss the evidence suggesting that publication bias, inability to replicate, and specification searching remain widespread in the discipline. We next discuss recent progress in this area, including through improved research design, study registration and pre-analysis plans, disclosure standards, and open sharing of data and materials, drawing on experiences in both economics and other social sciences. We discuss areas where consensus is emerging on new practices, as well as approaches that remain controversial, and speculate about the most effective ways to make economics research more credible in the future.
2016 saw a tremendous amount of discussion and development on the subject of scientific reproducibility. Were you able to keep up? If not, check out this list of 16 sources from 2016 to get you up to date for the new year! The reproducibility crisis in science refers to the difficulty scientists have faced in reproducing or replicating results from previously published scientific experiments. Although this crisis has existed in the scientific community for a very long time, it gained much more visibility in in the past few years. The terms “reproducibility crisis” and “replicability crisis” were coined in the early 2010s due to the growing awareness of the problem.
In recent years, the psychological and behavioral sciences have increased efforts to strengthen methodological practices and publication standards, with the ultimate goal of enhancing the value and reproducibility of published reports. These issues are especially important in the multidisciplinary field of psychophysiology, which yields rich and complex data sets with a large number of observations. In addition, the technological tools and analysis methods available in the field of psychophysiology are continually evolving, widening the array of techniques and approaches available to researchers. This special issue presents articles detailing rigorous and systematic evaluations of tasks, measures, materials, analysis approaches, and statistical practices in a variety of subdisciplines of psychophysiology. These articles highlight challenges in conducting and interpreting psychophysiological research and provide data-driven, evidence-based recommendations for overcoming those challenges to produce robust, reproducible results in the field of psychophysiology.