Reproducibility and transparency in biomedical sciences

The biomedical research sciences are currently facing a challenge highlighted in several recent publications: concerns about the rigor and reproducibility of studies published in the scientific literature.Research progress is strongly dependent on published work. Basic science researchers build on their own prior work and the published findings of other researchers. This work becomes the foundation for preclinical and clinical research aimed at developing innovative new diagnostic tools and disease therapies. At each of the stages of research, scientific rigor and reproducibility are critical, and the financial and ethical stakes rise as drug development research moves through these stages.