Is there a reproducibility "crisis" in biomedical science? No, but there is a reproducibility problem

Most scientists I know get a chuckle out of the Journal of Irreproducible Results (JIR), a humor journal that often parodies scientific papers. Back in the day, we used to chuckle at articles like "Any Eye for an Eye for an Arm and a Leg: Applied Dysfunctional Measurement" and "A Double Blind Efficacy Trial of Placebos, Extra Strength Placebos and Generic Placebos." Unfortunately, these days, reporting on science is giving the impression that the JIR is a little too close to the truth, at least when it comes to reproduciblity, so much so that the issue even has its own name and Wikipedia entry: Replication (or reproducibility) crisis.