Posts about reproducible paper (old posts, page 10)

Video can make science more open, transparent, robust, and reproducible

Amidst the recent flood of concerns about transparency and reproducibility in the behavioral and clinical sciences, we suggest a simple, inexpensive, easy-to-implement, and uniquely powerful tool to improve the reproducibility of scientific research and accelerate progress—video recordings of experimental procedures. Widespread use of video for documenting procedures could make moot disagreements about whether empirical replications truly reproduced the original experimental conditions. We call on researchers, funders, and journals to make commonplace the collection and open sharing of video-recorded procedures.

Ethical and legal implications of the methodological crisis in neuroimaging

Currently, many scientific fields such as psychology or biomedicine face a methodological crisis concerning the reproducibility, replicability and validity of their research. In neuroimaging, similar methodological concerns have taken hold of the field and researchers are working frantically towards finding solutions for the methodological problems specific to neuroimaging. This paper examines some ethical and legal implications of this methodological crisis in neuroimaging. With respect to ethical challenges, the paper discusses the impact of flawed methods in neuroimaging research in cognitive and clinical neuroscience, particulyrly with respect to faulty brain-based models of human cognition, behavior and personality. Specifically examined is whether such faulty models, when they are applied to neurological or psychiatric diseases, could put patients at risk and whether this places special obligations upon researchers using neuroimaging. In the legal domain, the actual use of neuroimaging as evidence in U.S. courtrooms is surveyed, followed by an examination of ways the methodological problems may create challenges for the criminal justice system. Finally, the paper reviews and promotes some promising ideas and initiatives from within the neuroimaging community for addressing the methodological problems.

Structuring supplemental materials in support of reproducibility

Supplements are increasingly important to the scientific record, particularly in genomics. However, they are often underutilized. Optimally, supplements should make results findable, accessible, interoperable, and reusable (i.e., “FAIR”). Moreover, properly off-loading to them the data and detail in a paper could make the main text more readable. We propose a hierarchical organization for supplements, with some parts paralleling and “shadowing” the main text and other elements branching off from it, and we suggest a specific formatting to make this structure explicit. Furthermore, sections of the supplement could be presented in multiple scientific “dialects”, including machine-readable and lay-friendly formats.

AI buzzwords explained: scientific workflows

The reproducibility of scientific experiments is crucial for corroborating, consolidating and reusing new scientific discoveries. However, the constant pressure for publishing results (Fanelli, 2010) has removed reproducibility from the agenda of many researchers: in a recent survey published in Nature (with more than 1500 scientists) over 70% of the participants recognize to have failed to reproduce the work from another colleague at some point in time (Baker, 2016). Analyses from psychology and cancer biology show reproducibility rates below 40% and 10% respectively (Collaboration, 2015) (Begley & Lee, 2012). As a consequence, retractions of publications have occurred in the last years in several disciplines (Marcus & Oransky, 2014) (Rockoff, 2015), and the general public is now skeptical about scientific studies on topics like pesticides, depression drugs or flu pandemics (American, 2010).

The role of the IACUC in ensuring research reproducibility

There is a "village" of people impacting research reproducibility, such as funding panels, the IACUC and its support staff, institutional leaders, investigators, veterinarians, animal facilities, and professional journals. IACUCs can contribute to research reproducibility by ensuring that reviews of animal use requests, program self-assessments and post-approval monitoring programs are sufficiently thorough, the animal model is appropriate for testing the hypothesis, animal care and use is conducted in a manner that is compliant with external and institutional requirements, and extraneous variables are minimized. The persons comprising the village also must have a shared vision that guards against reproducibility problems while simultaneously avoids being viewed as a burden to research. This review analyzes and discusses aspects of the IACUC's "must do" and "can do" activities that impact the ability of a study to be reproduced. We believe that the IACUC, with support from and when working synergistically with other entities in the village, can contribute to minimizing unintended research variables and strengthen research reproducibility.

A very simple, re-executable neuroimaging publication

Reproducible research is a key element of the scientific process. Re-executability of neuroimaging workflows that lead to the conclusions arrived at in the literature has not yet been sufficiently addressed and adopted by the neuroimaging community. In this paper, we document a set of procedures, which include supplemental additions to a manuscript, that unambiguously define the data, workflow, execution environment and results of a neuroimaging analysis, in order to generate a verifiable re-executable publication. Re-executability provides a starting point for examination of the generalizability and reproducibility of a given finding.